L’assentament humà des de la prehistòria fins al baix Imperi

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EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor

ACKNOWLEDGEMENTS We thank J. M. Valverde (IRB) as well as the NMR facilities of the University of Barcelona (CCiT UB) and the Instituto de Química Física Rocasolano (IQFR, CSIC) for their assistance in, respectively, protein production and NMR. This work was supported by IRB, ICREA (X.S.), Obra Social “la Caixa” (Fellowship to E.D.M. and CancerTec grants to X.S.) MICINN (CTQ2009-08850 to X.S.), MINECO (BIO2012-31043 to X.S.; CTQ2014-56361-P to A.R), Marató de TV3 (102030 to X.S. and 102031 to E.E.P) the COFUND programme of the European Commission (C.T.W.P., A. R. and X.S.), the European Research Council (CONCERT, contract number 648201, to X.S.), the Ramón y Cajal program of MICINN (RYC-2011-07873 to C.W.B.) the Serra Hunter Programme (E.E.P.) and AGAUR (SGR-2014-56RR14 to E.E.P). IRB Barcelona is the recipient of a Severo Ochoa Award of Excellence from MINECO (Government of Spain)Peer reviewedPostprin

The KASCADE-Grande Experiment and the LOPES Project

KASCADE-Grande is the extension of the multi-detector setup KASCADE to cover a primary cosmic ray energy range from 100 TeV to 1 EeV. The enlarged EAS experiment provides comprehensive observations of cosmic rays in the energy region around the knee. Grande is an array of 700 x 700 sqm equipped with 37 plastic scintillator stations sensitive to measure energy deposits and arrival times of air shower particles. LOPES is a small radio antenna array to operate in conjunction with KASCADE-Grande in order to calibrate the radio emission from cosmic ray air showers. Status and capabilities of the KASCADE-Grande experiment and the LOPES project are presented.Comment: To appear in Nuclear Physics B, Proceedings Supplements, as part of the volume for the CRIS 2004, Cosmic Ray International Seminar: GZK and Surrounding

Preservation of probiotic strains isolated from kefir by spray drying

Aims: This work aims to investigate the survival of Lactobacillus kefir CIDCA 8348, Lactobacillus plantarum CIDCA 83114 and Saccharomyces lipolytica CIDCA 812, all isolated from kefir, during spray drying and subsequent storage. Methods and Results: Micro-organisms were grown in De Man, Rogosa, Sharpe (MRS) or yeast medium (YM) medium and harvested in the stationary phase of growth. The thermotolerance in skim milk (D and Z values), the survival of spray drying at different outlet air temperatures and subsequent storage in different conditions during 150 days were studied. The resistance to the heat treatments was higher in Lact. plantarum compared to Lact. kefir and S. lipolytica. The three micro-organisms studied varied considerably in their ability to survive to spray drying processes. Lactobacillus plantarum showed the highest survival rate for all the tested outlet air temperatures and also to the further storage in the dried state. The survival rates of Lact. kefir and S. lipolytica through drying and subsequent storage in the dried state decreased when the drying outlet air temperatures increased. Conclusions: Spray drying is a suitable method to preserve micro-organisms isolated from kefir grains. A high proportion of cells were still viable after 80 days of storage at refrigerated temperatures Significance and Impact of Study: It is the first report about spray-dried probiotic strains isolated from kefir grain and contributes to the knowledge about these micro-organisms for their future application in novel dehydrated products.Facultad de Ciencias ExactasCentro de Investigación y Desarrollo en Criotecnología de Alimento

Distortions of Experimental Muon Arrival Time Distributions of Extensive Air Showers by the Observation Conditions

Event-by-event measured arrival time distributions of Extensive Air Shower (EAS) muons are affected and distorted by various interrelated effects which originate from the time resolution of the timing detectors, from fluctuations of the reference time and the number (multiplicity) of detected muons spanning the arrival time distribution of the individual EAS events. The origin of these effects is discussed, and different correction procedures, which involve detailed simulations, are proposed and illustrated. The discussed distortions are relevant for relatively small observation distances (R < 200 m) from the EAS core. Their significance decreases with increasing observation distance and increasing primary energies. Local arrival time distributions which refer to the observed arrival time of the first local muon prove to be less sensitive to the mass of the primary. This feature points to the necessity of arrival time measurements with additional information on the curvature of the EAS disk.Comment: 10 pages, 6 figures, accepted for publication in Astroparticle Physic

Weaving Concurrency in eXecutable Domain-Specific Modeling Languages

International audienceThe emergence of modern concurrent systems (e.g., Cyber-Physical Systems or the Internet of Things) and highly-parallel platforms (e.g., many-core, GPGPU pipelines, and distributed platforms) calls for Domain-Specific Modeling Languages (DSMLs) where concurrency is of paramount importance. Such DSMLs are intended to propose constructs with rich concurrency semantics, which allow system designers to precisely define and analyze system behaviors. However , specifying and implementing the execution semantics of such DSMLs can be a difficult, costly and error-prone task. Most of the time the concurrency model remains implicit and ad-hoc, embedded in the underlying execution environment. The lack of an explicit concurrency model prevents: the precise definition, the variation and the complete understanding of the semantics of the DSML, the effective usage of concurrency-aware analysis techniques, and the exploitation of the concurrency model during the system refinement (e.g., during its allocation on a specific platform). In this paper, we introduce a concurrent executable metamodeling approach, which supports a modular definition of the execution semantics , including the concurrency model, the semantic rules, and a well-defined and expressive communication protocol between them. Our approach comes with a dedicated metalanguage to specify the communication protocol, and with an execution environment to simulate executable models. We illustrate and validate our approach with an implementation of fUML, and discuss the modularity and applicability of our approach

Preservation of probiotic strains isolated from kefir by spray drying

Aims: This work aims to investigate the survival of Lactobacillus kefir CIDCA 8348, Lactobacillus plantarum CIDCA 83114 and Saccharomyces lipolytica CIDCA 812, all isolated from kefir, during spray drying and subsequent storage. Methods and Results: Micro-organisms were grown in De Man, Rogosa, Sharpe (MRS) or yeast medium (YM) medium and harvested in the stationary phase of growth. The thermotolerance in skim milk (D and Z values), the survival of spray drying at different outlet air temperatures and subsequent storage in different conditions during 150 days were studied. The resistance to the heat treatments was higher in Lact. plantarum compared to Lact. kefir and S. lipolytica. The three micro-organisms studied varied considerably in their ability to survive to spray drying processes. Lactobacillus plantarum showed the highest survival rate for all the tested outlet air temperatures and also to the further storage in the dried state. The survival rates of Lact. kefir and S. lipolytica through drying and subsequent storage in the dried state decreased when the drying outlet air temperatures increased. Conclusions: Spray drying is a suitable method to preserve micro-organisms isolated from kefir grains. A high proportion of cells were still viable after 80 days of storage at refrigerated temperatures Significance and Impact of Study: It is the first report about spray-dried probiotic strains isolated from kefir grain and contributes to the knowledge about these micro-organisms for their future application in novel dehydrated products.Facultad de Ciencias ExactasCentro de Investigación y Desarrollo en Criotecnología de Alimento

Long Range Magnetic Order and the Darwin Lagrangian

We simulate a finite system of $N$ confined electrons with inclusion of the Darwin magnetic interaction in two- and three-dimensions. The lowest energy states are located using the steepest descent quenching adapted for velocity dependent potentials. Below a critical density the ground state is a static Wigner lattice. For supercritical density the ground state has a non-zero kinetic energy. The critical density decreases with $N$ for exponential confinement but not for harmonic confinement. The lowest energy state also depends on the confinement and dimension: an antiferromagnetic cluster forms for harmonic confinement in two dimensions.Comment: 5 figure

Sugars separation in a fermentative broth by simulated moving bed chromatography : SMB

Des sucres tels que les fructo-oligosaccharides (FOS) sont bénéfiques pour leurs hôtes car ils stimulent la croissance de bactéries bénéfiques dans le colon du fait qu’ils ne sont pas digérés par l’organisme. Ces FOS peuvent être produits à grande échelle par un procédé de fermentation du sucrose dont le milieu résultant (FOS + autres sucres + sels) doit être séparé en ses différents constituants afin de respecter les normes agroalimentaires. Parmi les techniques permettant cette séparation, seule la chromatographie liquide est applicable à grande échelle afin d’obtenir les puretés requises. La technique de séparation par lit mobile simulé (Simulated Moving Bed – SMB) permet de rendre le procédé continu et de diminuer la consommation d’éluant tout en augmentant la productivité. L’efficacité des techniques chromatographiques dépendant en grande partie de la nature de l’adsorbant, une étude préliminaire a été réalisée dans le but d’identifier le meilleur adsorbant pour cette séparation. Une résine échangeuse d’ions choisie, différentes techniques d’identification des paramètres de fonctionnement ont été mises en oeuvre afin de tester la séparation en mode SMB. Les résultats obtenus permettent de montrer qu’à partir d’un milieu de fermentation contenant 40% de FOS, il est possible d’obtenir un produit final pur à plus de 80%. Néanmoins, il a été mis en évidence que si la présence de sucrose dans le milieu de fermentation est inévitable, il faut absolument la contrôler au maximum pour éviter la pollution du produit finalFructooligosaccharides (FOS) are non-digestible sugars which affect positively the host by stimulating the growth of specific bacteria in the colon. At large scale, FOS can be produced from sucrose through fermentation. The fermentative broth obtained from this process is a complex mixture. The application of these sugars in the food industry requires their fractionation in order to meet final product specifications. Simulated moving bed chromatography (SMB) appears to be an efficient downstream process for the fractionation of sugars at an industrial scale. Thanks to this technique it is possible to work continuously reducing the solvent consumption and increasing the productivity. The major challenge when designing the separation process is the choice of an efficient adsorbent. A preliminary study was thus realized in order to identify the best adsorbent. An ion exchange resin was chosen and several parametric identification techniques were performed in order to realize the SMB separation. The results display the possibility to increase the FOS purity from 40% to 80%. Nevertheless, it was also displayed that sucrose present in the broth troubles the separation and must be strictly controlled during the fermentation